CVRM Research at AstraZeneca in Gothenburg

Join the Cardiovascular Renal and Metabolism (CVRM) Research – Metabolism In Vitro Team at AstraZeneca in Gothenburg. Apply today!

The AstraZeneca CVRM Research group in Gothenburg is seeking a high calibre scientist to enable progression of a growing drug project portfolio. Highly motivated scientist is encouraged to apply for the opportunity to join our team of professionals who are passionate about advancing science, to discover and develop novel therapeutics that will benefit patients.

Purpose, Offer and Benefits

This is a 1-year consulting assignment starting in early November. You will be employed by TNG during the assignment.

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because an opportunity no matter how small can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognising their potential.

Your Responsibilities

• Responsibility for design, execution and analysis of in vitro and ex vivo assays.
• Communicate results, conclusions and recommendations to colleagues, line manager and the project team.
• Record experiments in lab books and databases according to AstraZeneca policy.
• Play a leading role in assay development and optimisation of in vitro assays.
• You would report to an expert member of staff and would be encouraged to be able to plan your daily work within direction set by your supervisor.

You will:

• Provide interpretation of assay results.
• Work within a line and/or matrix/project team.
• Demonstrates scientific rigor in assessing own data and that of others.
• Be a "hands-on" expert with in vitro models and methodologies.

The Bigger Picture

This position will be laboratory based and you will be responsible for several technical and experimental processes to support the CVRM Research group.

You will play an active role in implementing and executing scientific research within a CVRM Metabolism project, enabling studies aimed at exploring disease modifying mechanisms linked to pharmacological inhibition of the biological target of interest. This is a "hands-on," laboratory based scientific and technical role in our in vitro metabolism team supporting projects from target validation to lead optimisation phases.

Our Expectations

• Ability to develop new methods, technologies, and processes
• Enthusiasm for laboratory work, scientific curiosity.
• Experience in running in vitro biochemical and cellular assays to provide potency and activity readouts, including use of primary and recombinant cell lines.
• Significant cell culture experience.
• Experience with disease relevant cell types such as primary hepatocytes or hepatocyte-like cell lines in 2D cultures.
• Experience with ex vivo analysis of blood/tissue samples (including qPCR for gene expression, Western blots, and ELISA).
• Experience in data analysis and interpretation and enthusiasm for problem solving for scientifically challenging work.
• Demonstrable ability to work within a line and/or matrix/ cross-functional project team.
• Strong interest in providing materials and data for scientifically challenging work.
• Strong organisational, time management and communication skills.
• Strong, demonstrable analytical ability.
• Good oral and written communications skills.