Preclinical DMPK lead at AstraZeneca

Do you want to join AstraZeneca’s vibrant R&D site in Gothenburg as a Senior Scientist - Preclinical DMPK lead? Apply today!

Are you a scientist with expertise in mathematical modelling with an application in drug discovery?
Would you like to apply your expertise in a global company that follows the science and turns ideas into life-changing medicines? Then you could be the new colleague we are looking for! You will be part of the DMPK Department within Early Respiratory & Immunology (R&I) as a Preclinical DMPK lead (with a focus on translational PK and PKPD modelling). This position is located at AstraZeneca’s vibrant R&D site in Gothenburg.

Purpose, Offer and Benefits

At AstraZeneca, we are proud to have an outstanding workplace culture that encourages innovation and teamwork. We are united by our vision to push the boundaries of DMPK science to transform ideas into medicines for R&I patients. Employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.

Your Responsibilities

Duties and Responsibilities:

• Develop and apply PKPD models to influence decision making in drug discovery and development
• Assist in dose to man (DtM) predictions and perform uncertainty analysis thereof
• Use PKPD modelling to inform and influence the design of preclinical PKPD studies and contribute to estimation of safety margins
• Active engagement and scientific collaboration with the internal modelling community

The Bigger Picture

AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialization of prescription medicines for some of the world´s most serious diseases. At AstraZeneca, we are proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives and are made to feel valued, energized and rewarded for their ideas and creativity.

This position is a 1 year consulting assignment, this means that you will be employed by TNG during this time. 

Our Expectations

Essential for the role

• Hands-on experience of PKPD modelling. Experience can have been gained from empirical PKPD models or quantitative systems pharmacology (QSP) models, by means of tools like Phoenix, Matlab, R, Monolix, NONMEM or similar.
• PhD/MSc in either pharmacokinetics or pharmacology or from another related field, with a focus on mathematical modelling of PKPD data, ideally in a preclinical/translational setting
• Good communication skills in English, both verbal and in writing are required
• Excellent interpersonal skills that lead to successful collaborative working relationships and ability to work independently in cross-functional teams on a day-to-day basis.